Klomipramina

Klomipramina
Formula kimikoa	C19H23ClN2
SMILES kanonikoa	2D eredua
MolView	3D eredua
Mota	organonitrogen heterocyclic compound (en) , monochlorobenzene (en) eta tertiary amine (en)
Masa molekularra	314,155 Da
Erabilera
Konposatu aktiboa	Anafranil
Tratatzen du	min, Izu-nahasmendu, nahasmendu neurotiko, nahasmendu obsesibo-konpultsibo eta nahasmendu obsesibo-konpultsibo
Interakzioak	isocarboxazid (en) , phenelzine (en) , procarbazine (en) , (±)-deprenyl (en) , tranylcypromine (en) , disopyramide (en) , droperidol (en) , haloperidol, klorpromazina, Zitalopram, pimozide (en) , moxifloxazino, zuklopentixol, Hidroxizina, venlafaxine (en) , Metadona, mefloquine (en) , loxapine (en) , sotalol (en) , litio, trimipramine (en) , Amitriptilina, (S)-duloxetine (en) , Paroxetina, Sertralina, Fluboxamina, Fluoxetina, imipramina, Zitalopram, nabumetone (en) , Naproxeno, celecoxib (en) , diklofenako, Piroxicam, Meloxikam, (RS)-fenoprofen (en) , (±)-flurbiprofen (en) , Ibuprofeno, indometazina, (RS)-ketoprofen (en) , (RS)-etodolac (en) , sulindac (en) , parecoxib (en) , aceclofenac (en) , tenoxicam (en) , trimipramine (en) , Amitriptilina, phenelzine (en) , droperidol (en) , pimozide (en) , haloperidol, ketiapina, imipramina, klorpromazina, Enalapril, propranolol, sotalol (en) , clonidina, zuklopentixol, klozapina, litio, disopyramide (en) , disopyramide (en) , disopyramide (en) , trimipramine (en) , Amitriptilina, imipramina, prometazina, sotalol (en) , ketiapina, klozapina, petidina, tapentadol (en) , tramadol, fentanil, phenelzine (en) , phenelzine (en) , phenelzine (en) , phenelzine (en) , linezolid (en) , linezolid (en) , linezolid (en) , linezolid (en) , moclobemide (en) , moclobemide (en) , moclobemide (en) , moclobemide (en) , vortioxetine (en) , vortioxetine (en) , vortioxetine (en) , vortioxetine (en) , nabumetone (en) , Naproxeno, celecoxib (en) , diklofenako, Piroxicam, Meloxikam, (RS)-fenoprofen (en) , (±)-flurbiprofen (en) , Ibuprofeno, indometazina, (RS)-ketoprofen (en) , (RS)-etodolac (en) , sulindac (en) , parecoxib (en) , aceclofenac (en) , tenoxicam (en) , noradrenalina, noradrenalina, noradrenalina, adrenalina, adrenalina, adrenalina, propranolol, (RS)-nefopam (en) , (S)-duloxetine (en) , (S)-duloxetine (en) , (S)-duloxetine (en) , Paroxetina, Bupropion, Fluoxetina, loxapine (en) , loxapine (en) , loxapine (en) , loxapine (en) , Fluboxamina, Fluboxamina, Fluboxamina, venlafaxine (en) , venlafaxine (en) , Metadona, Enalapril, Enalapril eta Enalapril
Elkarrekintza	solute carrier family 6 member 3 (en) , Potassium inwardly-rectifying channel, subfamily J, member 6 (en) , Potassium inwardly-rectifying channel, subfamily J, member 5 (en) , Solute carrier family 6 member 2 (en) eta solute carrier family 6 member 4 (en)
Haurdunaldia	Australian pregnancy category C (en) eta US pregnancy category C (en)
Rola	selective serotonin reuptake inhibitor (en) , adrenergic uptake inhibitors (en) , tricyclic antidepressant (en) eta farmako esentzial
Identifikatzaileak
InChlKey	GDLIGKIOYRNHDA-UHFFFAOYSA-N
CAS zenbakia	303-49-1
ChemSpider	2699
PubChem	2801
Reaxys	1323477
Gmelin	47780
ChEMBL	CHEMBL415
EC zenbakia	206-144-2
ECHA	100.005.587
MeSH	D002997
RxNorm	2597
Human Metabolome Database	HMDB0015372
UNII	NUV44L116D
NDF-RT	N0000147779
KEGG	D07727
PDB Ligand	CXX

Klomipramina antidepresibo trizikliko bat da^[1]. Hainbat gaixotasun tratatzeko erabiltzen da, batez ere nahasmendu obsesibo-konpultsiboa. Ohikoa da ere hiperakusian, izu-nahasmenduan, depresio-nahasmendu larrian, trikotilomanian^[2], gorputz dismorfikoaren nahasmenduan^[3] eta min kronikoan. Eragin nabarmena izan du eiakulazio goiztiarraren tratamenduan eta narkolepsiari lotutako kataplexian^[4]. Kataplexiaz gain, baliteke haluzinazio hipnanogiko eta hipnoponpikoetan eragina izatea, baina ez dago hain ebidentzia sendoa^[5]. Beste antidepresibo batzuetan bezala, suizidio arriskua areagotu dezake 25 urtetik beherakoen artean, gutxienez tratamenduaren lehenengo asteetan^[1].

Erreferentziak

↑ ^a ^b (Ingelesez) «ClomiPRAMINE Monograph for Professionals» Drugs.com (kontsulta data: 2025-01-01).
↑ (Ingelesez) Swedo, Susan E.; Leonard, Henrietta L.; Rapoport, Judith L.; Lenane, Marge C.; Goldberger, Erica L.; Cheslow, Deborah L.. (1989-08-24). «A Double-Blind Comparison of Clomipramine and Desipramine in the Treatment of Trichotillomania (Hair Pulling)» New England Journal of Medicine 321 (8): 497–501. doi:10.1056/NEJM198908243210803. ISSN 0028-4793. (kontsulta data: 2025-01-01).
↑ (Ingelesez) Adebayo, Kazeem Olaide; Gureje, Oye; Nuhu, Tajudeen Folorunsho. (2012-11). «Body Dysmorphic Disorder in a Nigerian Boy Presenting as Depression: A Case Report and Literature Review» The International Journal of Psychiatry in Medicine 44 (4): 367–372. doi:10.2190/PM.44.4.f. ISSN 0091-2174. (kontsulta data: 2025-01-01).
↑ (Ingelesez) Dauvilliers, Yves; Siegel, Jerry M.; Lopez, Regis; Torontali, Zoltan A.; Peever, John H.. (2014-07). «Cataplexy—clinical aspects, pathophysiology and management strategy» Nature Reviews Neurology 10 (7): 386–395. doi:10.1038/nrneurol.2014.97. ISSN 1759-4758. PMID 24890646. PMC PMC8788644. (kontsulta data: 2025-01-01).
↑ Chen, C. N.. (1980). «The use of clomipramine as an REM sleep suppressant in narcolepsy» Postgraduate Medical Journal 56 Suppl 1: 86–89. ISSN 0032-5473. PMID 7393833. (kontsulta data: 2025-01-01).

Kanpo estekak

Datuak: Q58713
Multimedia: Clomipramine / Q58713

[drugs-1] (Ingelesez) «ClomiPRAMINE Monograph for Professionals» Drugs.com (kontsulta data: 2025-01-01).

[2] (Ingelesez) Swedo, Susan E.; Leonard, Henrietta L.; Rapoport, Judith L.; Lenane, Marge C.; Goldberger, Erica L.; Cheslow, Deborah L.. (1989-08-24). «A Double-Blind Comparison of Clomipramine and Desipramine in the Treatment of Trichotillomania (Hair Pulling)» New England Journal of Medicine 321 (8): 497–501. doi:10.1056/NEJM198908243210803. ISSN 0028-4793. (kontsulta data: 2025-01-01).

[3] (Ingelesez) Adebayo, Kazeem Olaide; Gureje, Oye; Nuhu, Tajudeen Folorunsho. (2012-11). «Body Dysmorphic Disorder in a Nigerian Boy Presenting as Depression: A Case Report and Literature Review» The International Journal of Psychiatry in Medicine 44 (4): 367–372. doi:10.2190/PM.44.4.f. ISSN 0091-2174. (kontsulta data: 2025-01-01).

[4] (Ingelesez) Dauvilliers, Yves; Siegel, Jerry M.; Lopez, Regis; Torontali, Zoltan A.; Peever, John H.. (2014-07). «Cataplexy—clinical aspects, pathophysiology and management strategy» Nature Reviews Neurology 10 (7): 386–395. doi:10.1038/nrneurol.2014.97. ISSN 1759-4758. PMID 24890646. PMC PMC8788644. (kontsulta data: 2025-01-01).

[5] Chen, C. N.. (1980). «The use of clomipramine as an REM sleep suppressant in narcolepsy» Postgraduate Medical Journal 56 Suppl 1: 86–89. ISSN 0032-5473. PMID 7393833. (kontsulta data: 2025-01-01).

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