AASDHPPT

AASDHPPT
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	2BYD, 2C43, 2CG5
Identifikatzaileak
Aliasak	AASDHPPT (HUGO), AASD-PPT, LYS2, LYS5, CGI-80, ACPS, aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Kanpoko IDak	OMIM: 607756 MGI: 1914868 HomoloGene: 9130 GeneCards: AASDHPPT OMA: AASDHPPT - orthologs
Genearen kokapena (gizakia)
	Kromosoma: 11 (gizakia)
Amaiera	106.098.699 bp
Genearen kokapena (sagua)
	Kromosoma: 9 (sagua)
Amaiera	4.309.471 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	esperma ; ; Epithelium of choroid plexus ; ; frontal pole ; ; postcentral gyrus ; ; Brodmann area 23 ; ; superior frontal gyrus ; ; superior vestibular nucleus ; ; Entzefaloaren enborreko zubia; ; cerebellar vermis ; ; orbitofrontal cortex ;
	Adierazpen ohikoena
	esku; ; endocardial cushion ; ; balbula aurikulobentrikular ; ; Paneth cell ; ; spermatocyte ; ; abdominal wall ; ; left lobe of liver ; ; urothelium ; ; transitional epithelium of urinary bladder ; ; muskulu soleo;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	transferase activity ; proteina lotura ; magnesium ion binding ; metal ion binding ; holo-[acyl-carrier-protein synthase activity] ;
Zelularen osagaia	zitoplasma ; zitosol ; extracellular exosome ;
Prozesu biologikoa	lysine biosynthetic process via aminoadipic acid ; pantothenate metabolic process ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	60496
	67618
	ENSG00000149313
	ENSMUSG00000025894
	Q9NRN7
	Q9CQF6
	NM_015423
	NM_026276; NM_001326359
	NP_056238
	NP_001313288; NP_080552
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

L-aminoadipata-semialdehido dehidrogenasa-fosfopanteteinil transferasa entzima bat da, gizakietan AASDHPPT geneak kodetzen duena^[5]^[6].

Proteina Saccharomyces cerevisiaeren LYS5 bezalakoa da, beharrezkoa dena alfa-aminoadipato dehidrogenasaren aktibaziorako lisinaren bide biosintetikoan. Legamiaren alfa-aminoadipato dehidrogenasak alfa-aminoadipato-biosintetikoa alfa-aminoadipatoan bilakatzen du. Uste da gizakiengan gene honen akatsek azidemia pipekolikoa sortzen dutela^[7].

Erreferentziak

↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025894 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Joshi, Anil K.; Zhang, Lei; Rangan, Vangipuram S.; Smith, Stuart. (2003-08). «Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity» Journal of Biological Chemistry 278 (35): 33142–33149. doi:10.1074/jbc.m305459200. ISSN 0021-9258. (Noiz kontsultatua: 2024-10-06).
↑ Praphanphoj, Verayuth; Sacksteder, Katherine A.; Gould, Stephen J.; Thomas, George H.; Geraghty, Michael T.. (2001-04-01). «Identification of the α-Aminoadipic Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase Gene, the Human Ortholog of the Yeast LYS5 Gene» Molecular Genetics and Metabolism 72 (4): 336–342. doi:10.1006/mgme.2000.3138. ISSN 1096-7192. (Noiz kontsultatua: 2024-10-06).
↑ «AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Homo sapiens (human) - Gene - NCBI»] www.ncbi.nlm.nih.gov (Noiz kontsultatua: 2024-10-06).

Kanpo estekak

Datuak: Q18045386

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025894 – Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Joshi, Anil K.; Zhang, Lei; Rangan, Vangipuram S.; Smith, Stuart. (2003-08). «Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity» Journal of Biological Chemistry 278 (35): 33142–33149. doi:10.1074/jbc.m305459200. ISSN 0021-9258. (Noiz kontsultatua: 2024-10-06).

[6] Praphanphoj, Verayuth; Sacksteder, Katherine A.; Gould, Stephen J.; Thomas, George H.; Geraghty, Michael T.. (2001-04-01). «Identification of the α-Aminoadipic Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase Gene, the Human Ortholog of the Yeast LYS5 Gene» Molecular Genetics and Metabolism 72 (4): 336–342. doi:10.1006/mgme.2000.3138. ISSN 1096-7192. (Noiz kontsultatua: 2024-10-06).

[7] «AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Homo sapiens (human) - Gene - NCBI»] www.ncbi.nlm.nih.gov (Noiz kontsultatua: 2024-10-06).

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