Akkermansia muciniphila

Akkermansia muciniphila
Sailkapen zientifikoa
Erreinua	Pseudomonadati
Filuma	Verrucomicrobiota
Klasea	Verrucomicrobiia
Ordena	Verrucomicrobiales
Familia	Akkermansiaceae
Generoa	Akkermansia
Espeziea	Akkermansia muciniphila; [[\|]]
Datu orokorrak
Gram tindaketa	bakterio gram-negatibo

Akkermansia muciniphila Akkermansia generoko bakterioa da, gure heste-floran dagoena. Hestean dagoen muzina erabiltzen du, proteina hori izanik bere karbono eta nitrogeno iturria nagusia.

Giza hesteetan ez ezik, hainbat animaliren hesteetan ere bizi da ^[1].

Bakterio Gram negatiboa da, anaerobio hertsia, ez da mugikorra eta ez du esporarik sortzen.

Bakterio honen gabezia asaldura eta gaixotasun batzuekin lotu da: obesitatea, 2. motako diabetesa eta hesteetako hantura kronikoarekin, besteak beste ^[2] ^[3] ^[4]. Era berean, 2018an egindako ikerketa batek agerian jarri zuen bakterio honek tumore epitelialen immunoterapia-tratamenduan laguntzen zuela ^[5]

Erreferentziak

↑ Van Passel MW, Kant R, Zoetendal EG, et al. (2011) The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes
↑ Akkermansia muciniphila: la bacteria que se correlaciona con salud inmunológica, metabólica y envejecimiento saludable ICNS Instituto (2019)
↑ Everard, A.; Belzer, C.; Geurts, L.; Ouwerkerk, J. P.; Druart, C.; Bindels, L. B.; Guiot, Y.; Derrien, M. et al. (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Proceedings of the National Academy of Sciences 110 (22): 9066-9071
↑ Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling ScienceDirect (2015)
↑ Bertrand Routy et al., Gut microbiote influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science, 359, 91, 2018

Kanpo estekak

Datuak: Q15020908
Espezieak: Akkermansia muciniphila

[1] Van Passel MW, Kant R, Zoetendal EG, et al. (2011) The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

[2] Akkermansia muciniphila: la bacteria que se correlaciona con salud inmunológica, metabólica y envejecimiento saludable ICNS Instituto (2019)

[3] Everard, A.; Belzer, C.; Geurts, L.; Ouwerkerk, J. P.; Druart, C.; Bindels, L. B.; Guiot, Y.; Derrien, M. et al. (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Proceedings of the National Academy of Sciences 110 (22): 9066-9071

[4] Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling ScienceDirect (2015)

[5] Bertrand Routy et al., Gut microbiote influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science, 359, 91, 2018

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