Kafestol

Kafestol
Formula kimikoa	C20H28O3
SMILES kanonikoa	2D eredua
SMILES isomerikoa	C[C@@]12CCc3c(cco3)[C@H]1CC[C@]45[C@H]2CC[C@H](C4)[C@](C5)(CO)O
MolView	3D eredua
Konposizioa	karbono
Mota	[[17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0¹,¹³.0⁴,¹².0⁵,⁹]nonadeca-5(9),6-dien-17-ol\|17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0¹,¹³.0⁴,¹².0⁵,⁹]nonadeca-5(9),6-dien-17-ol]] (en)
Estereoisomeroa	[[(1S,4S,12S,13R,16S,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-ol\|(1S,4S,12S,13R,16S,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-ol]] (en)
Ezaugarriak
Fusio-puntua	158 ℃
Masa molekularra	316,203844756 Da
Identifikatzaileak
InChlKey	DNJVYWXIDISQRD-HWUKTEKMSA-N
CAS zenbakia	469-83-0
ChemSpider	10289419
PubChem	108052
Gmelin	3291
UNII	AC465T6Q6W
KEGG	C09066

Kafetola ${\ce {C20H38O3}}$ formula duen diterpenoa da, kafe-landarearen aleetan aurkitzen dena, hortik bere izena. Coffea arabica-ren ale baten pisuaren %0,6 inguru hartzen du kafestolak^[1].

Osasuna

Ikerketek azaldu dutenez irakindako kafea hartzeak kolesterol maila handitzen du, %8a gizonezkoetan eta %10a emakumezkoetan. Iragazitako kafeak nabarmen gutxitzen du efektua, iragazkian gelditzen baitira diterpenoak^[2].

Animalietan efektu onuragarriak ikusi zaizkio kafestolari. Arratoietan minbiziaren aurka egiten du eta Drosophila eltxoetan Parkinsonen gaixotasunari egiten dio aurre^[3].

Erreferentziak

↑ (Ingelesez) «Bioactive compounds content in roasted coffee from traditional and modern Coffea arabica cultivars grown under the same edapho-climatic conditions» Food Research International 61: 61–66. 2014-07-01 doi:10.1016/j.foodres.2014.04.031. ISSN 0963-9969. (kontsulta data: 2018-12-30).
↑ (Ingelesez) «Cafestol extraction yield from different coffee brew mechanisms» Food Research International 49 (1): 27–31. 2012-11-01 doi:10.1016/j.foodres.2012.06.032. ISSN 0963-9969. (kontsulta data: 2018-12-30).
↑ (Ingelesez) Pallanck, Leo; Gelb, Michael; Lee, Daewoo; Hanak, Tyler; Krause, James; Andrews, Laurie; Trinh, Kien. (2010-04-21). «Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism» Journal of Neuroscience 30 (16): 5525–5532. doi:10.1523/JNEUROSCI.4777-09.2010. ISSN 1529-2401. PMID 20410106. (kontsulta data: 2018-12-30).

Kanpo estekak

Datuak: Q423829
Multimedia: Cafestol / Q423829

[1] (Ingelesez) «Bioactive compounds content in roasted coffee from traditional and modern Coffea arabica cultivars grown under the same edapho-climatic conditions» Food Research International 61: 61–66. 2014-07-01 doi:10.1016/j.foodres.2014.04.031. ISSN 0963-9969. (kontsulta data: 2018-12-30).

[2] (Ingelesez) «Cafestol extraction yield from different coffee brew mechanisms» Food Research International 49 (1): 27–31. 2012-11-01 doi:10.1016/j.foodres.2012.06.032. ISSN 0963-9969. (kontsulta data: 2018-12-30).

[3] (Ingelesez) Pallanck, Leo; Gelb, Michael; Lee, Daewoo; Hanak, Tyler; Krause, James; Andrews, Laurie; Trinh, Kien. (2010-04-21). «Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism» Journal of Neuroscience 30 (16): 5525–5532. doi:10.1523/JNEUROSCI.4777-09.2010. ISSN 1529-2401. PMID 20410106. (kontsulta data: 2018-12-30).

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