Lanosterol

Lanosterol
Formula kimikoa	C30H50O
SMILES kanonikoa	2D eredua
SMILES isomerikoa	C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C
MolView	3D eredua
Konposizioa	karbono
Mota	Esterol eta [[(3S,10S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3S,10S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en)
Estereoisomeroa	(+)-tirucallol (en) , [[(3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3S,5R,10S,13S,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3S,5R,10S,13S,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3R,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3R,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3S,5S,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3S,5S,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3R,5R,10S,13S,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol\|(3R,5R,10S,13S,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) eta Euphol (en)
Masa molekularra	426,386 Da
Erabilera
Rola	primary metabolite (en)
Identifikatzaileak
InChlKey	CAHGCLMLTWQZNJ-BQNIITSRSA-N
CAS zenbakia	79-63-0
ChemSpider	216175
PubChem	246983
Reaxys	2226449
Gmelin	16521
ChEMBL	CHEMBL225111
EC zenbakia	201-214-9
ECHA	100.001.105
CosIng	34865
MeSH	D007810
RxNorm	1442199
Human Metabolome Database	HMDB0001251
KNApSAcK	C00003657
UNII	1J05Z83K3M
KEGG	C01724
PDB Ligand	LAN

Lanosterola esterolen saileko alkohola da (C₂₈H₄₄O). Mutur batean daukan hidroxilo taldeari esker molekula anfipatikoa da.

Biosintesia[aldatu | aldatu iturburu kodea]

Eskualeno izeneko triterpenotik ekoizten da eta lanosterola oinarri hartuta eratzen dira gainerako esteroideak.

Osasuna[aldatu | aldatu iturburu kodea]

Azken ikerketek erakutsi dute ugaztunetan begi-lausoa edo "katarata" sortzea ekiditen duela^[1].

Erreferentziak[aldatu | aldatu iturburu kodea]

↑ (Ingelesez) Zhang, Kang; Yan, Yong-Bin; Liu, Yizhi; Zhang, Liangfang; Wang, Jun; Sun, Xiaodong; Li, Yingrui; Granet, David et al.. (2015-07). «Lanosterol reverses protein aggregation in cataracts» Nature 523 (7562): 607–611. doi:10.1038/nature14650. ISSN 1476-4687. (Noiz kontsultatua: 2018-12-30).

Kanpo estekak[aldatu | aldatu iturburu kodea]

Datuak: Q414996
Multimedia: Lanosterol / Q414996

[1] (Ingelesez) Zhang, Kang; Yan, Yong-Bin; Liu, Yizhi; Zhang, Liangfang; Wang, Jun; Sun, Xiaodong; Li, Yingrui; Granet, David et al.. (2015-07). «Lanosterol reverses protein aggregation in cataracts» Nature 523 (7562): 607–611. doi:10.1038/nature14650. ISSN 1476-4687. (Noiz kontsultatua: 2018-12-30).

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